acute and chronic glomerulonephritis pdf

Acute And Chronic Glomerulonephritis Pdf

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Acute on Chronic Kidney Disease

Arch Intern Med. Efficient and timely diagnosis is essential in these situations because progression to end-stage renal disease may result if the underlying disease is not promptly treated. Glomerular injury leads to impairment of the selective filtering properties of the kidney and reduction in the glomerular filtration rate GFR. The nature and severity of the defect ie, underlying disease and pathologic lesion determine the quantity of red blood cells RBC , white blood cells, and proteins lost in the urine and the extent of functional impairment. While the GFR is reduced initially in many patients, the severity, reversibility, and progression of disease are dependent on many factors, including the nature, location, and extent of the insult and the renal and systemic response to glomerular injury.

Glomerulonephritis is a disorder of glomeruli clusters of microscopic blood vessels in the kidneys with small pores through which blood is filtered. It is characterized by body tissue swelling edema , high blood pressure, and the presence of red blood cells in the urine. Glomerulonephritis can be caused by various disorders, such as infections, an inherited genetic disorder, or autoimmune disorders. Diagnosis is based on tests of blood and urine and sometimes imaging tests, a biopsy of the kidneys, or both. People often need to restrict salt and protein intake and take diuretics or antibiotics until kidney function improves.

Glomerulonephritis is the name given to a range of conditions that can affect the kidney, specifically the glomeruli of the kidney. The glomeruli become damaged, commonly because of a problem with the body's immune system. Many people with glomerulonephritis may not notice any symptoms initially. However, salt and excess fluid can build up in the body if the glomeruli and kidneys are not working normally. This can lead to complications such as high blood pressure and, in some cases, chronic kidney disease, which may lead to end-stage kidney disease. Treatment will depend on the underlying cause as well as the severity of symptoms.

Acute Kidney Injury: A Guide to Diagnosis and Management

Glomerulonephritis refers to a range of inflammatory kidney conditions of the tiny blood vessels in the kidneys, known as glomeruli. It can be acute, which means it starts suddenly, or chronic, during which the onset is gradual. Either type can be fatal. Kidney disease affects 4. The glomeruli act as tiny filters within the kidneys. Each kidney contains millions of glomeruli.

Blood enters your kidneys through your renal arteries. Your kidneys remove excess fluid and waste material from your blood through units called nephrons. Each nephron contains a filter glomerulus that has a network of tiny blood vessels called capillaries. The glomeruli filter waste products and substances your body needs — such as sodium, phosphorus and potassium — which then pass through tiny tubules. The substances your body needs are reabsorbed into your bloodstream. The waste products flow through the ureters — the tubes that lead to the bladder.

Renal biopsy: obligatory for confirmation of the diagnosis, differential diagnosis between acute and chronic glomerulonephritis and definition of morphological.


Glomerulonephritis is a group of diseases that injure the part of the kidney that filters blood called glomeruli. Other terms you may hear used are nephritis and nephrotic syndrome. When the kidney is injured, it cannot get rid of wastes and extra fluid in the body.

Professional Reference articles are designed for health professionals to use. You may find the Acute Kidney Injury article more useful, or one of our other health articles. NICE has issued rapid update guidelines in relation to many of these.

The Journal publishes articles on basic or clinical research relating to nephrology, arterial hypertension, dialysis and kidney transplants. It is governed by the peer review system and all original papers are subject to internal assessment and external reviews. The journal accepts submissions of articles in English and in Spanish languages. The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two receding years.

What is glomerulonephritis?

Javascript is currently disabled in your browser. Several features of this site will not function whilst javascript is disabled. Published 14 May Volume Pages 49—

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A more recent article on acute kidney injury is available.


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