contradicted and initially stronger effects in highly cited clinical research pdf

Contradicted And Initially Stronger Effects In Highly Cited Clinical Research Pdf

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Obtaining negative or contradicting results, whereas conducting a study has always been overlooked as inadequacies on the part of the researcher. Many-a-times, negative results are arrived at even after conducting the study with great care and effort. This cannot be considered, a flaw, always.

How Often Does Correlation=Causality?

Join our discussions. Replication is of great importance to science, because science aims to discover laws of nature. Since such laws are permanent, experiments on which they are based should be infinitely replicable [1]. This concept is highly important to medicine. Being able to replicate, for example, an epidemiologic study to determine health effects of certain risk factors could build up existing scientific evidence and impact decision making that might affect the public health [2]. Replicability also represents a direct public interest since science is significantly funded by public resources.

There is increasing concern that most current published research findings are false. The probability that a research claim is true may depend on study power and bias, the number of other studies on the same question, and, importantly, the ratio of true to no relationships among the relationships probed in each scientific field. In this framework, a research finding is less likely to be true when the studies conducted in a field are smaller; when effect sizes are smaller; when there is a greater number and lesser preselection of tested relationships; where there is greater flexibility in designs, definitions, outcomes, and analytical modes; when there is greater financial and other interest and prejudice; and when more teams are involved in a scientific field in chase of statistical significance. Simulations show that for most study designs and settings, it is more likely for a research claim to be false than true. Moreover, for many current scientific fields, claimed research findings may often be simply accurate measures of the prevailing bias. In this essay, I discuss the implications of these problems for the conduct and interpretation of research. Topics: Essay.

Replicability

The journal, published since , is the official publication of the Spanish Society of Cardiology and founder of the REC Publications journal family. Articles are published in both English an Spanish in its electronic edition. The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two receding years. CiteScore measures average citations received per document published. Read more. SRJ is a prestige metric based on the idea that not all citations are the same. SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal's impact.

The UK is one of the largest funders of health research in the world, but little is known about how health funding is spent. Our study explores whether major UK public and charitable health research funders support the research of UK-based scientists producing the most highly-cited research. To address this question, we searched for UK-based authors of peer-reviewed papers that were published between January and February and received over citations in Scopus. Of those, are still in UK academic institutions, while 59 are not currently in UK academia have left the country, are retired, or work in other sectors. Only 7 out of board members 1.

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Read article at publisher's site DOI : Strayhorn JM. Nguyen TV. Osteoporos Sarcopenia , 6 4 , 28 Nov

Contradicted and Initially Stronger Effects in Highly Cited Clinical Research

Download to read the full article text. Mayor S. Surgery journal bans authors who hide conflicts of interest. BMJ ;

Metrics details. Randomised controlled trials RCTs provide the most reliable information to inform clinical practice and patient care. We aimed to map global clinical research publication activity through RCT-related articles in high-impact-factor medical journals over the past five decades.

Publications

Беккер стоял с закрытыми глазами, а человек в очках в металлической оправе приближался к. Где-то неподалеку зазвонил колокол. Беккер молча ждал выстрела, который должен оборвать его жизнь. ГЛАВА 89 Лучи утреннего солнца едва успели коснуться крыш Севильи и лабиринта узких улочек под. Колокола на башне Гиральда созывали людей на утреннюю мессу. Этой минуты ждали все жители города.

Contradicted and initially stronger effects in highly cited clinical research.

Там открывался вид на стоянку автомобилей агентства, а из окна комнаты для заседаний был виден внушительный ряд корпусов АНБ - в том числе и купол шифровалки, это вместилище высочайших технологий, возведенное отдельно от основного здания и окруженное тремя акрами красивого парка. Шифровалку намеренно разместили за естественной ширмой из высоченных кленов, и ее не было видно из большинства окон комплекса АНБ, а вот отсюда открывался потрясающий вид - как будто специально для директора, чтобы он мог свободно обозревать свои владения.

Замечательный город. Я бы хотел задержаться. - Значит, вы видели башню. Гиральду.

В кабине стоял какой-то мужчина. Беккер успел заметить лишь очки в железной оправе. Мужчина поднес к носу платок. Беккер вежливо улыбнулся и вышел на улицу - в душную севильскую ночь. ГЛАВА 42 Вернувшись в комнату, Сьюзан, не находя себе места, нервно ходила из угла в угол, терзаясь мыслью о том, что так и не выбрала момент, чтобы разоблачить Хейла.

Сьюзан должна была признать, что прозвучало это довольно убедительно. У Танкадо не было причин подозревать, что код в Интернете не является оригиналом. Никто не имел к нему доступа, кроме него самого и Северной Дакоты.

И в тот же миг осознала свою ошибку.

5 comments

Curtis D.

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Joshua B.

Conclusions Contradiction and initially stronger effects are not unusual in highly cited research of clinical interventions and their outcomes.

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Altea V.

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Kamille C.

Eisenach articulately develops a plan for Anesthesiology to deal with what is arguably the largest case of author misconduct in our specialty's history.

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